A case of Lambert-Eaton myasthenic syndrome with possible myasthenia gravis
Iqbal, M.; Connolly, S.; Langan, Y.; Redmond, J.
Irish Medical Journal 105(6): 183-184
2012
ISSN/ISBN: 0332-3102 PMID: 22973658 Document Number: 662841
Lambert-Eaton myasthenic syndrome (LEMS) is a rare autoimmune disorder of neuromuscular transmission (NMJ) that shares many clinical features with myasthenia gravis (MG). We report a 73 year-old lady who presented 10 years previously with stiffness of both calves, dry mouth, fatigue, proximal weakness and areflexia in lower limbs. Neurophysiological studies were consistent with LEMS. Her work up for an underlying neoplasm was negative. She recently developed unilateral ptosis and diplopia which dramatically improved with pyridostigmine suggesting concomitant MG.