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A role of WNT in kidney development and function

Mesar, I.; Kes, P.; Jukić, N.B.ć

Acta Medica Croatica Casopis Hravatske Akademije Medicinskih Znanosti 66(Suppl 2): 56-58

2012

ISSN/ISBN: 1330-0164
PMID: 23513417
Document Number: 662638
WNT 4 is a secreted glycoprotein that is critical for nephrogenesis during mesenchymal to epithelial transformation. Lately there are some experimental modles witch confirm a role of Wnt 4 during regeneration process in acute renal failure. On the other hand there are some evidence that Wnt 4 plays important role in renal fibrosis during experimental renal injury in rats that provide tubuloinerstitial fibrosis. When will Wnt 4 have a protective role or when will induce fibrosis still is not known and therefore futher studies will be necessary to gain a more precise understanding.

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