Drug chronotherapy: the coordination of biological rhythms with medical treatment
Ando, H.; Fujimura, A.
Nihon Rinsho. Japanese Journal of Clinical Medicine 70(7): 1222-1226
2012
ISSN/ISBN: 0047-1852 PMID: 22844809 Document Number: 662449
Chronotherapy is defined as a coordination of biological rhythms with medical treatment. At present, several medications, including bronchodilating agents and H2 blockers, are administered with consideration for biological rhythms in routine clinical practice. In addition, recent studies have revealed that bedtime administration of antihypertensive medications can ameliorate the disturbed circadian rhythm of blood pressure and improve the prognosis in patients with hypertension. Because chronotherapy is a simple and inexpensive method of optimizing safe and effective pharmacotherapy, merits of this therapy should be evaluated in many medications.