Bronchial asthma: new prospects in therapy
Terapevticheskii Arkhiv 84(3): 5-11
2012
ISSN/ISBN: 0040-3660 PMID: 22708415 Document Number: 661905
The article reviews original and literature data on the use of monoclonal antibodies (MAB) for treatment of patients with severe bronchial asthma (BA), methods of MAB obtaining. Biomolecule targets in BA are some immunoglobulins, CD4 Iymphocytes and TNFalpha. Successful use of monoclonal anti-IgE antibodies in BA by Russian clinicians in 1980s and current experience with administration of foreign MAB drugs (omalizumab, mepolizumab, infliximab, etc.) are considered.