Comparison of blood biochemical indices in rats exposed to lead in macrodispersed form and nanoform
Lazarenko, I.A.; Mel'nykova, N.M.
Ukrains'kyi Biokhimichnyi Zhurnal 84(1): 85-89
2012
ISSN/ISBN: 0372-3909 PMID: 22679762 Document Number: 660753
It is shown that the increasing content of lead in blood (6.3 and 3.7 times) and liver (30.1 and 4.6 times) in rats after 14-days per os exposure both to lead acetate (macrodispersed form) and lead nanoparticles (nanoform) in a dose of 7 mg/100 g of body weight leads to the increased of activity of blood enzymes: alanine aminotransferase, aspartate aminotransferase, gamma-glutamyltransferase, alkaline phosphatase, lactate dehydrogenase and a decrease of creatinine level. Lead in nanoform with slight accumulation, due to the greater elimination, expressed higher biological activity and reactivity as compared to macrodispersed form. Thus the exposure to lead in different dispersed form suggests metabolic disorders in rats, and accumulation of lead and biochemical changes are more expressed in the liver.