Drug interactions of psychotropic drugs
Sawada, Y.; Satoh, H.
Nihon Rinsho. Japanese Journal of Clinical Medicine 70(1): 27-41
2012
ISSN/ISBN: 0047-1852 PMID: 22413489 Document Number: 660130
For the appropriate use of psychotropic drugs, such as hypnotics, antidepressants and antipsychotics, knowledge of the pharmacokinetic characteristics and the interactions of these drugs are required. The mechanisms of drug interaction can be subdivided into pharmacokinetic interactions and pharmacodynamic interactions. Among the former, interactions involving inhibition or induction of cytochrome P450 (CYP) enzymes are clinically very important. If such interactions cause an increase of systemic exposure to psychotropic drugs, adverse effects are likely, while a decrease exposure may lead to treatment failure. In this article, we review drug interactions of psychotropic drugs from the viewpoints of clinical evidence, mechanism, and management.