Diffusion tensor imaging analyses of white matter in healthy siblings of schizophrenics
Kang, Z.; Wei, Q.-l.; Tang, Y.-x.; Li, L.-j.; Zheng, L.-r.; Guo, X.-f.; Zhang, J.-b.; Zhao, J.-p.
Zhonghua Yi Xue Za Zhi 92(39): 2772-2774
2012
ISSN/ISBN: 0376-2491 PMID: 23290166 Document Number: 659703
To explore the diffusion tensor imaging (DTI) features of white matter in healthy siblings of schizophrenics. Twenty healthy siblings of schizophrenics and 45 healthy controls without a family history of mental disorder. They responded to advertised recruitment during December 2009 and March 2012. All participants underwent diffusion weighted magnetic resonance images with a single-shot echo planar imaging (EPI) sequence aligned to straight axial plane. The fractional anisotropy (FA) images of two groups underwent two-sample t-test with SPM5 software. The healthy siblings of schizophrenics demonstrated a significant decrease of regional white matter FA values in right anterior cingulated (MNI: x = 9, y = 43, z = 4; cluster = 106). Reduced white matter integrity in right anterior cingulated may be a risk actor of schizophrenia.