Impact of laser therapy on PGE2 level, 24-hour pH-metry changes, and quality of life in patients with gastroesophageal reflux disease
Burduli, N.M.; Tadtaeva, D.I.
Terapevticheskii Arkhiv 84(12): 58-61
2012
ISSN/ISBN: 0040-3660 PMID: 23479991 Document Number: 659288
To study the impact of low-intensity laser irradiation on 24-hour pH-metry parameters and prostaglandin E2 (PGE2) levels in patients with gastroesophageal reflux disease (GERD). One hundred and twelve patients aged 19 to 79 years with GERD were examined. Seventy-eight patients received a 10-day course of continuous intravenous laser therapy using a Matrix VLOK laser therapy apparatus (Matrix, Russia) with a wavelength of 0.405 pm, radiation power at the exit of a main light guide 1-1.5 mW, pulse rate 80 Hz. The indicators under study were determined before and after treatment. After treatment, the intravenous laser therapy group showed a significant increase in PGE2 (1376 +/- 93 pg/ml) to the levels typical of those in healthy individuals and a significant decrease in all esophageal pH-metry parameters; the DeMeester score achieved normal values, and all quality of life (QL) indicators, except for physical function index, significantly improved (10.2 +/- 5.7; p < 0.05). The findings are suggestive of elevated PGE2 levels and improved QL during laser therapy.