Three clinical cases of nonrespiratory acidosis in kidney transplant recipients receiving anti-CMV therapy
Kabat-Koperska, J.; Kędzierska, K.; Gołembiewska, E.; Marchelek-Myśliwiec, M.łg.; Dutkiewicz, G.ży.; Ciechanowski, K.
Annals of Transplantation 17(2): 135-140
2012
ISSN/ISBN: 2329-0358 PMID: 22743733 Document Number: 659172
To preserve kidney graft function it is necessary to use ganciclovir or valganciclovir as a therapy for fresh CMV infection or prophylaxis in high-risk kidney transplant recipients. Ganciclovir-induced lactic acidosis has thus far not been reported. Three cases of nonrespiratory acidosis in kidney transplant recipients receiving ganciclovir or valganciclovir as anti-CMV therapy or prophylaxis are presented. Lactic acidosis developed in 2 patients, and the other patient had nonrespiratory acidosis of unknown origin. The possible mechanism of the development of lactic acidosis in presented cases is explored. The analysis of the described cases cannot eliminate the potential negative influence of anti-CMV therapy on acid-base equilibrium, especially with coexisting active viral infection.