Studies on metabolism of total terpene ketones from Swertia mussotii with human intestinal bacteria
Li, S.; Tian, C.-W.; Wu, S.; Yang, X.-W.; Wang, L.-L.; Zhang, T.-J.
Zhongguo Zhong Yao Za Zhi 37(24): 3743-3747
2012
ISSN/ISBN: 1001-5302 PMID: 23627171 Document Number: 659113
To study the metabolism of total terpene ketones from Swertia mussotii with human intestinal bacteria. Total terpene ketones were incubated with human intestinal bacteria under an anaerobic environment and at 37 degrees C. The metabolites were extracted by ethyl acetate processing, detected by HPLC-DAD method. A qualitative analysis was made for its metabolites by HPLC-MS. Eight metabolites were detected from total terpene ketones from S. mussotii with human intestinal bacteria, and two of them were preliminarily identified as gentianine and mangiferin aglycon. Total terpene ketones can be metabolized with human intestinal bacteria, which provides basis for experiments on the metabolism process total terpene ketones from S. mussotii with human intestinal bacteria.