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Effect of dendritic cell autovaccine on the treatment outcome in patients with ovarian cancer

Khranovskaia, N.N.; Grinevich, I.A.; Potebnia, G.P.; Vorod'eva, L.I.; Svintsitskiĭ, V.S.; Tsin, N.P.; Skachkova, O.V.; Sit'ko, V.V.; Lisovenko, G.S.; Tanacienko, O.A.; Svergun, N.N.; Mel'nik, V.A.; Gorbach, A.I.; Nikulina, V.V.

Voprosy Onkologii 58(6): 781-786

2012

ISSN/ISBN: 0507-3758
PMID: 23600304
Document Number: 658995
During I/II phase clinical trial in ovarian cancer (OC) patients two types of autologous anticancer vaccines based on dendritic cells have been tested, and a comparative analysis of their effectiveness have been performed. It was shown that the anticancer vaccines based on DC, "loaded" with autologous tumor cell lysate obtained by treatment of tumor cells by cytotoxic lectins B. subtilis had higher efficiency, compared with the standard DC--autovaccine. The presence of antigen-specific immune response observed after at least four vaccinations. Obtained results open the prospects to improve the basic treatment of OC patients by this method. The results of immunological examinations create preconditions for individual optimization of the DC-vaccine therapy.

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