Estradiol + nomegestrol. Oral contraceptive claimed to be more natural, but presenting no obvious advantages
Prescrire international 21(133): 292
2012
ISSN/ISBN: 1167-7422 PMID: 23373095 Document Number: 658471
No evidence of an advantage over standard oestrogen-progestin combinations, but as many serious adverse effects as with ethinylestradiol + drospirenone.
Document emailed within 1 workday
Related Documents
Gaussem, P.; Alhenc-Gelas, M.; Thomas, J.-L.; Bachelot-Loza, C.; Remones, V.; Ali, F.D.; Aiach, M.; Scarabin, P.-Y. 2011: Haemostatic effects of a new combined oral contraceptive, nomegestrol acetate/17β-estradiol, compared with those of levonorgestrel/ethinyl estradiol. a double-blind, randomised study Thrombosis and Haemostasis 105(3): 560-567Pintiaux, A.; Gaspard, U.; Nisolle, M. 2012: Zoely, a combined oral contraceptive, monophasic pill containing estradiol and nomegestrol acetate Revue Medicale de Liege 67(3): 152-156
Grandi, G.; Napolitano, A.; Xholli, A.; Tirelli, A.; Di Carlo, C.; Cagnacci, A. 2015: Effect of oral contraceptives containing estradiol and nomegestrol acetate or ethinyl-estradiol and chlormadinone acetate on primary dysmenorrhea Gynecological Endocrinology: the Official Journal of the International Society of Gynecological Endocrinology 31(10): 774-778
Burke, A. 2013: Nomegestrol acetate-17b-estradiol for oral contraception Patient Preference and Adherence 7: 607-619
Mansour, D.; Verhoeven, C.; Sommer, W.; Weisberg, E.; Taneepanichskul, S.; Melis, G.B.; Sundström-Poromaa, I.; Korver, T. 2011: Efficacy and tolerability of a monophasic combined oral contraceptive containing nomegestrol acetate and 17β-oestradiol in a 24/4 regimen, in comparison to an oral contraceptive containing ethinylestradiol and drospirenone in a 21/7 regimen European Journal of Contraception and Reproductive Health Care: the Official Journal of the European Society of Contraception 16(6): 430-443
Molina, R.C.; Sandoval, J.Z.; Montero, A.V.; Oyarzún, P.G.; Molina, T.ís.G.; González, E.A. 2009: Comparative performance of a combined injectable contraceptive (50 mg norethisterone enanthate plus 5mg estradiol valerate) and a combined oral contraceptive (0.15 mg levonorgestrel plus 0.03 mg ethinyl estradiol) in adolescents Journal of Pediatric and Adolescent Gynecology 22(1): 25-31
Oner, G.; Muderris, I.I. 2011: A prospective randomized trial comparing low-dose ethinyl estradiol and drospirenone 24/4 combined oral contraceptive vs. ethinyl estradiol and drospirenone 21/7 combined oral contraceptive in the treatment of hirsutism Contraception 84(5): 508-511
Krishnan, S.; Kiley, J. 2010: The lowest-dose, extended-cycle combined oral contraceptive pill with continuous ethinyl estradiol in the United States: a review of the literature on ethinyl estradiol 20 μg/levonorgestrel 100 μg + ethinyl estradiol 10 μg International Journal of Women's Health 2: 235-239
De Kam, P.-J.; van Kuijk, J.; Lillin, O.; Post, T.; Thomsen, T. 2014: The effect of therapeutic and supratherapeutic oral doses of nomegestrol acetate (NOMAC)/17β-estradiol (E2) on QTcF intervals in healthy women: results from a randomized, double-blind, placebo- and positive-controlled trial Clinical Drug Investigation 34(6): 413-420
Ågren, U.M.; Anttila, M.; Mäenpää-Liukko, K.; Rantala, M.-L.; Rautiainen, H.; Sommer, W.F.; Mommers, E. 2011: Effects of a monophasic combined oral contraceptive containing nomegestrol acetate and 17β-oestradiol in comparison to one containing levonorgestrel and ethinylestradiol on markers of endocrine function European Journal of Contraception and Reproductive Health Care: the Official Journal of the European Society of Contraception 16(6): 458-467
Jensen, J.T.; Archer, D.F.; Westhoff, C.L.; Nelson, A.L.; Graham, S.; Bernick, B. 2023: Satisfaction with a Segesterone Acetate and Ethinyl Estradiol Contraceptive Vaginal System Among Recent Oral Contraceptive or Hormonal Contraceptive Vaginal Ring Users Journal of Women's Health 32(7): 808-815
Hofmann, B.; Reinecke, I.; Schuett, B.; Merz, M.; Zurth, C. 2014: Pharmacokinetic overview of ethinyl estradiol dose and bioavailability using two transdermal contraceptive systems and a standard combined oral contraceptive International Journal of Clinical Pharmacology and Therapeutics 52(12): 1059-1070
Ndefo, U.Anadu.; Mosely, N. 2010: Estradiol valerate and estradiol valerate/dienogest (natazia) tablets: the first four-phasic oral contraceptive P and T: a Peer-Reviewed Journal for Formulary Management 35(11): 614-617
Endrikat, J.; Parke, S.; Trummer, D.; Serrani, M.; Duijkers, I.; Klipping, C. 2013: Pituitary, ovarian and additional contraceptive effects of an estradiol-based combined oral contraceptive: results of a randomized, open-label study Contraception 87(2): 227-234
Hauzman, E.E.; Zapata, A.; Bermejo, A.; Iglesias, C.; Pellicer, A.; Garcia-Velasco, J.A. 2013: Cycle scheduling for in vitro fertilization with oral contraceptive pills versus oral estradiol valerate: a randomized, controlled trial Reproductive Biology and Endocrinology: Rb&e 11: 96
Borgelt, L.M.; Martell, C.W. 2012: Estradiol valerate/dienogest: a novel combined oral contraceptive Clinical Therapeutics 34(1): 37-55
Akerlund, M. 1997: Clinical experience of a combined oral contraceptive with very low dose ethinyl estradiol Acta Obstetricia et Gynecologica Scandinavica. Suppl 164: 63-65
De Leo, V.; Fruzzetti, F.; Musacchio, M.C.; Scolaro, V.; Di Sabatino, A.; Morgante, G. 2013: Effect of a new oral contraceptive with estradiol valerate/dienogest on carbohydrate metabolism Contraception 88(3): 364-368
Rekers, H. 1988: Multicenter trial of a monophasic oral contraceptive containing ethinyl estradiol and desogestrel Acta Obstetricia et Gynecologica Scandinavica 67(2): 171-174
Hanson, F.W.; Niswander, K.R. 1974: A new low dose norethindrone acetate (0.6 mg) ethinyl estradiol (30 mcg) combination oral contraceptive Journal of Reproductive Medicine 12(3): 109-111