An effect of continuous and intermittent renal replacement therapy on antibiotic treatment in critically ill patients with sepsis - a practice-based perspective of vancomycin and gentamycin therapies
Petejová, N.; Martínek, A.; Zahálková, J.; Duricová, J.; Plášek, J.; Valkovský, I.; Grundmann, M.; Kacířová, I.
Vnitrni Lekarstvi 58(6): 448-454
2012
ISSN/ISBN: 0042-773X PMID: 22913237 Document Number: 657450
Sepsis and septic shock are common cause of hospitalisation in intensive care unit. Acute kidney injury is an accompanying manifestation of sepsis/septic shock leading to worsening of morbidity and also mortality and requiring use of intermittent or continual renal replacement therapy. Life saving effect is attributed to early and effective antibiotic therapy. Therapeutic drug monitoring and do-sage adjustment is important for successful treatment. Despite therapeutic drug monitoring of both antibiotic agents vankomycin and gentamicin the treatment still rises many questions about the convenient use in septic patients due to their nephrotoxicity.