Clinical analysis of 134 cases of HEV-related liver failure
Zhu, B.; You, S.-L.; Zang, H.; Rong, Y.-H.; Zhang, A.-M.; Li, C.; Chen, J.; Liu, H.-L.; Wan, Z.-H.; Xin, S.-J.
Zhonghua Shi Yan he Lin Chuang Bing du Xue Za Zhi 26(4): 301-303
2012
ISSN/ISBN: 1003-9279 PMID: 23189851 Document Number: 657208
To study the clinical features of hepatitis E virus-related liver failure. 134 patients with HEV-related liver failure were analyzed retrospectively. HEV-related liver failure accounted for 8.45 percent of the total number of hepatitis E patients in the hospital. Of the 134 patients, 68 were infected with simple HEV, 66 had the superinfection with HBV. The average age of simple HEV-related liver failure patients (56.12 +/- 14.29) was higher than that of HBV superinfectiong liver failure patients (P < 0.05). The ratio of elderly patients (> or = 60 years) in simple HEV-related liver failure patients (45.59%) was significantly higher than that of the other group (13.64%, P < 0.05). The ratio of direct bilirubin/total bilirubing (0.72 +/- 0.07, 0.69 +/- 0.08), and serum alanine aminotransferase [(1250.90 +/- 1593.97) U/L, (616.26 +/- 797.62) U/L] were significantly higher in simple HEV-related liver failure patients than in HBV superinfectiong liver failure patients (P < 0.05), but the total bilirubing had no significant difference (P > 0.05). The disease outcome and stage were no-significant difference in the two groups (P > 0.05). CONCLUSION; Simple HEV-related liver failure patients may have older age, higher aminotransferase, higher ratio of direct bilirubin/total bilirubin, but disease outcome and stage were no-significant difference in the two groups.