Risk factors for recurrence of stage Ii colon cancer
Okamoto, Y.; Kawamura, T.; Sakai, T.; Mitsutsuji, M.; Oshikiri, T.; Kamoda, Y.; Takase, N.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 38(10): 1633-1637
2011
ISSN/ISBN: 0385-0684 PMID: 21996958 Document Number: 655887
This study was designed to clarify risk factors for the recurrence of stage II colon cancer in patients and to determine possible treatment options for postoperative adjuvant chemotherapy. The subjects were 132 patients with stage II colon cancer who underwent surgery in this department from January 1998 to December 2007. Various high risk factors for recurrence and factors indicative of poor prognosis were examined (age, gender, site of tumor, maximum tumor diameter, invasion depth, histopathological classification, D number, ly, v, number of biopsied lymph nodes, preoperative tumor marker values and presence of postoperative adjuvant therapy). The group with postoperative adjuvant therapy had a better prognosis than the others (p=0. 0168). Groups with an absence of postoperative adjuvant therapy (p=0. 041), presence of vessel involvement (p=0. 0127), and poorly-differentiated types (p=0. 027)were extracted in a multivariate analysis of risk factors for recurrence. Postoperative adjuvant therapy was effective for stage II colon cancer. Vessel involvement and poorly-differentiated types were risk factors for recurrence of stage II colon cancer.