Animal models for bone and joint disease. the genetically-modified mice as a tool for osteoporosis research
Ochi, H.; Takeda, S.
Clinical Calcium 21(2): 226-232
2011
ISSN/ISBN: 0917-5857 PMID: 21289419 Document Number: 655791
Recent advances of molecular genetics made it possible to generate genetically-modified mice. Furthermore, the discovery and application of Cre-loxP recombination system into mouse genetics led to study the function of a gene in a tissue-specific manner. Analyses of these mutant mice advanced our understanding of the molecular physiology and pathophisiology of skeletal tissue.