Roles of lipid mediators in controlling vascular inflammation and the progression of atherosclerosis
Endo, J.; Arita, M.
Nihon Rinsho. Japanese Journal of Clinical Medicine 69(1): 34-38
2011
ISSN/ISBN: 0047-1852 PMID: 21226257 Document Number: 655437
Atherosclerosis is recognized as an inflammatory condition of the vessel wall, characterized by accumulation of inflammatory cells such as macrophages and T cells. There are accumulating evidences that chemokines, cytokines, and lipid mediators coordinately modulate platelet- or leukocyte-endothelial cell interactions, and contribute to the maintenance of vascular homeostasis. This review focuses on the role of lipid mediators, especially those derived from polyunsaturated fatty acids, in controlling vascular inflammation and the progression of atherosclerosis.