Nevirapine nanosuspensions for HIV reservoir targeting
Shegokar, R.; Singh, K.K.
Die Pharmazie 66(6): 408-415
2011
ISSN/ISBN: 0031-7144 PMID: 21699078 Document Number: 655423
In this paper we discuss, production, characterization and in-vivo evaluation of nevirapine nanosuspensions. Laser diffraction showed that the average particles size was 457 nm. Following single-dose administration, the plasma gamma concentration profiles showed fast release. Macrophage uptake studies confirmed enhanced cellular uptake for nanonized nevirapine with no added cytotoxicity. Gamma scintigraphy showed that the nanosuspension prepared can be used to target spleen, thymus and lungs, which represent anatomical viral reservoirs. Thus nevirapine nanosuspensions with targeting potential have been prepared successfully.