Keratin fragments as a serological indicator in patients with a liver disease
Lata, J.; Mrlianová, H.; Stibůrek, O.; Nozicka, J.; Cermáková, Z.; Gottwaldová, J.; Drozd, P.
Vnitrni Lekarstvi 57(12): 1025-1028
2011
ISSN/ISBN: 0042-773X PMID: 22277036 Document Number: 654122
Determination of M30 antigen appears to be a sensitive method for evaluation of hepatocyte apoptosis. The aim of the present project was to implement this technique, compare M30 values in patients with a liver disease and healthy controls and to identify potential relationships between M30 values and other parameters. M30 antigen was assessed in 25 patients with a liver disease and 30 healthy controls. These results were compared between patients with a liver disease and the controls and correlated to a range of clinical and laboratory values, including tissue polypeptide-specific antigen (TPS), in patients with a liver disease. We found significant differences in M30 values between controls and patients with a liver disease. The only significant correlations were the correlation between M30 and ALT, highly significant correlation between M30 and AST and highly significant correlation between M30 and TPS. The M30 antigen is a sensitive indicator of liver damage. Considering the highly significant correlation with TPS, it can be assumed that in some liver diseases, TPS could serve as a clinically useful indicator of apoptosis.