Top Abstract Purchase Related
Home
>
Node
>
Subnode

Analysis of efficacy and safety of administration of moxonidine in patients with arterial hypertension and hypertensive crises

Gaponova, N.I.; Abdrakhmanov, V.R.; Baratashvili, V.L.; Tereshchenko, S.N.

Kardiologiia 51(6): 91-96

2011

ISSN/ISBN: 0022-9040
PMID: 21878076
Document Number: 653897
In the review we present detailed analysis of antihypertensive action of 3-nd generation sympatholytic moxonidine. Due to selective interaction with imidazoline I1-receptors moxonidine diminishes sympathetic activity causing lowering of peripheral vascular resistance. This leads to significant lowering of systolic and diastolic arterial pressure. Efficacy and safety of the drug has been shown both for the management of uncomplicated hypertensive crises and long term treatment of arterial hypertension (AH). Appropriateness of the use of moxonidine in patients with AH combined with diabetes mellitus, metabolic syndrome, chronic obstructive pulmonary disease has been confirmed. Moxonidine is well tolerated; its bioavailability after oral intake reaches 90%. The drug produces neither hypotensive "first dose" nor rebound effects.

Document emailed within 1 workday
Secure & encrypted payments

Pershakova, L.P.; Suchkov, V.V.; Koplik, E.V. 1977: Changes in the antidiuretic activity of the blood in hypertensive crises and experimental arterial hypertension of hypothalamic origin Kardiologiia 17(10): 27-31
Durongpisitkul, K.; Pornrattanarungsi, S.; Panjasamanvong, P.; Chungsomprasong, P. 2011: Efficacy and safety of high dose generic sildenafil in Thai patients with pulmonary arterial hypertension Journal of the Medical Association of Thailand 94(4): 421-426
Erhard, W.; Lindner, U.; Krall, H.; Breitstadt, A.; Pfeiffer, C. 1991: Assessment of the efficacy, tolerance, and safety of ramipril in diabetic patients with mild-to-moderate hypertension: a retrospective analysis Journal of Cardiovascular Pharmacology 18 Suppl. 2: S160-S164
Gao, H. 2019: Clinical efficacy and safety of benzbromarone in elderly hypertensive patients with hyperuricemia Pakistan Journal of Pharmaceutical Sciences 32(4 Supplary): 1869-1871
Wijaya, I.; Siregar, P. 2013: Hypertensive crises in the adolescent: evaluation of suspected renovascular hypertension Acta Medica Indonesiana 45(1): 49-54
Cugini, P. 1998: From Chronos to Chaos: from the determinism of circadian rhythm of arterial pressure to the undeterminism of hypertensive crises Recenti Progressi in Medicina 89(4): 188-199
Velasco-Cornejo, I.F.; Mion Júnior, D.; Martin, L.C.; Tinucci, T.; Sampaio, M.; Pascoal, I.J.; Athanázio-Heliodoro, R.C.; Marcondes, M.; Franco, R.J. 1994: Comparative and double-blind study of the efficacy and safety of cilazapril compared to nifedipine retard in the treatment of mild and moderate arterial hypertension Arquivos Brasileiros de Cardiologia 62(3): 159-164
Ambrosioni, E. 1994: Transdermal therapy of arterial hypertension: a new approach in the management of hypertensive patients Annali Italiani di Medicina Interna: Organo Ufficiale Della Societa Italiana di Medicina Interna 9 Suppl: 54s-57s
Babaev, A.A.; Rogoza, A.N.; Kosmacheva, E.D.; Panfilov, V.V.; At'kov, O.I. 1992: The baroreceptor reflex as a predictor of crises in arterial hypertension Kardiologiia 32(5): 26-28
Kulkarni, R.B.; Kulkarni, B.N.; Hariharan, R.S.; Naikwadi, A.; Gawde, A.; Baliga, V.; Desai, A. 2005: A pilot study for evaluation of the efficacy and safety of telmisartan in reducing microalbuminuria in hypertensive patients with type 2 diabetes mellitus Journal of the Indian Medical Association 103(3): 187-191
Buranakitjaroen, P.; Kittipawong, P.; Koanantakul, B.; Piamsomboon, C.; Prasassarakich, N.; Silaraks, S.; Sukonthasarn, A.; Tiyapant, A. 2003: Efficacy and safety of rilmenidine, a selective imidazoline I1 receptor binding ligand, in mild-to-moderate Thai hypertensive patients Journal of the Medical Association of Thailand 86(10): 903-910
Ponce Castro, H.; Rodríguez Gaytán, R.; Rodríguez Orozco, A.R. 2009: Efficacy of two methods of administration of salbutamol-ipratropium bromide in asthma crises Revista Alergia Mexico 56(5): 149-153
Ipatov, A.I.; Arabidze, G.G.; Tebloev, K.I.; Fishchenko, S.G. 2002: Clinical assessment of efficacy and safety of noliprel in patients with hypertension Kardiologiia 42(9): 49-52
Ivanov, A.P.; Saĭeda, E.A.; El'gardt, I.A.; Sdobniakova, N.S. 2009: Importance of detection of hypertensive reaction to physical loading in patients with or without left ventricular hypertrophy and arterial hypertension Klinicheskaia Meditsina 87(7): 24-26
de Aguiar, J.A. 1977: Blood pressure. Systemic arterial hypertension. Hypertensive arterial disease. A concept Amb: Revista da Associacao Medica Brasileira 23(2): 39-44
Celikić, S.; Dimcić, Z.; Matunović, A. 1986: Treatment of patients with hypertensive crises Vojnosanitetski Pregled 43(2): 162-165
Gordeuk, V.R. 2005: Efficacy and safety of sildenafil in the treatment of severe pulmonary hypertension in patients with hemoglobinopathies Haematologica 90(4): 433-434
Berdah, J.; Guest, M.; Salvador, M. 1998: Study of the efficacy and safety of fosinopril in general practice in 19,435 hypertensive patients (FLIGHT Study) Annales de Cardiologie et D'angeiologie 47(3): 169-175
Cugini, P.; De Rosa, R.; Coda, S.; De Francesco, G.P.; Fontana, S.; Pellegrino, A.M. 2001: Individualization of the "presumptive risk" of hypertensive crisis using fractals interpolation of the 24-hour arterial pressure. Study of patients with essential hypertension La Clinica Terapeutica 152(2): 95-99
Cugini, P.; Petrangeli, C.M.; Capodaglio, P.F.; Chiera, A.; Cruciani, F.; Turri, M.; Gherardi, F.; Santino, G. 1997: Minimal lesion hypertensive retinopathy and arterial pre-hypertension: evidence of arterial pressure monitoring in presumed normotensive subjects at zero risk Recenti Progressi in Medicina 88(1): 11-16