Chromosomal abnormalities in patients with recurrent spontaneous abortions in northeast China
Zhang, Z.; Gao, H.; Li, S.; Hong, M.; Liu, R.
Journal of Reproductive Medicine 56(7-8): 321-324
2011
ISSN/ISBN: 0024-7758 PMID: 21838162 Document Number: 653328
To investigate the ratio and types of chromosomal abnormalities in patients with recurrent spontaneous abortions (RSAs). In this study, cytogenetic results of 734 patients with RSA, 360 men and 374 women, were referred to Norman Bethune Medicine College, Jilin University, Changchun, China, from May 2004 to December 2009. Among these 734 patients, 172 were couples. Gbanded cytogenetic analysis was performed based on our standard laboratory protocols, and results were given based on International System for Human Cytogenetic Nomenclature 2005 and 2009. Of the total 734 patients, 22 patients were found to have abnormal karyotypes, which were believed to cause RSA. Eight of them were men (1.09%) and 14 were women (1.91%). The chromosomal abnormalities detected include reciprocal translocation (2.45%), dicentric abnormality (0.14%), Robertsonian translocation (0.27%), and inversion (0.14%). Chromosomal abnormality is an important cause of RSA. It is very important to provide chromosomal analysis service for patients with RSA, and it should be considered as a standard medical care.