Interleukin network in pulmonary tuberculosis
Matsuzaki, G.; Umemura, M.
Nihon Rinsho. Japanese Journal of Clinical Medicine 69(8): 1368-1372
2011
ISSN/ISBN: 0047-1852 PMID: 21838031 Document Number: 653202
Pulmonary tuberculosis is an infectious disease caused by Mycobacterium tuberculosis which establishes intracellular parasitism in phagosomes of macrophages as initial infection sites. When host immune system recognizes the bacteria, anti-mycobacterial immunity is activated by various cytokines including interleukins, tumor necrosis factor-alpha and interferon-gamma. The cytokines form a network of co-operative action and mutual regulation. In this review, role of the network of interleukins and cytokines in protection against pulmonary tuberculosis will be discussed.
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