Gastroprotective action of the nettle extract in experimental peptic ulcer
Burkova, V.N.; Boev, S.G.; Vengerovskiĭ, A.I.; Iudina, N.V.; Arbuzov, A.G.
Eksperimental'naia i Klinicheskaia Farmakologiia 74(1): 24-27
2011
ISSN/ISBN: 0869-2092 PMID: 21476271 Document Number: 652707
Nettle extract produced from leaves crushed to 40-70 nm fragments protects the stomach mucous membrane, and does it better than the extract derived from same leaves crushed to 1 mm fragments, on the models of peptic ulcers caused by acetylsalicylic acid, histamine, prednisolone, and immobilized stress. The antiulcer activity of the nettle extract from 40-70 nm fragments is comparable with the effect of buckthorn oil. Nettle extracts also hinder the excess acid secretion and diminish the acidity of stomach juice in experimental peptic ulcer caused by pylorus ligation.