Coverage of gingival recession defects using guided tissue regeneration with and without adjunctive enamel matrix derivative in a dog model
Fujita, T.; Yamamoto, S.; Ota, M.; Shibukawa, Y.; Yamada, S.
International Journal of Periodontics and Restorative Dentistry 31(3): 247-253
2011
ISSN/ISBN: 0198-7569 PMID: 21556381 Document Number: 651863
The aim of this study was to clarify the adjunctive effect of enamel matrix derivative (EMD) on expanded polytetrafluoroethylene membrane guided tissue regeneration (GTR)-based root coverage by creating gingival recessions in beagle dogs. Recessions were treated with GTR + EMD, GTR alone, or neither GTR nor EMD (control). The control group was characterized by long junctional epithelium and little bone formation. The GTR + EMD group showed a statistically significant increase (P < .01) in new bone and cementum formation compared with the GTR group. The results of the present investigation suggest that the adjunctive use of EMD with GTR promotes formation of new bone and cementum without root resorption in recession-type defects in dogs.