Iloprost in the management of peripheral arterial disease in patients with diabetes mellitus
Piaggesi, A.; Vallini, V.; Iacopi, E.; Tedeschi, A.; Scatena, A.; Goretti, C.; Rizzo, L.
Minerva Cardioangiologica 59(1): 101-108
2011
ISSN/ISBN: 0026-4725 PMID: 21285935 Document Number: 651611
Diabetic complications in the lower extremities, especially those secondary to diabetic macroangiopathy, have increasingly become a clinical emergency, given the high prevalence and progression of the disease. Until recently, the only approach to treating advanced stage disease was medical therapy and major amputation; however, the advent of revascularization procedures has radically improved the prognosis of patients with critical lower limb ischemia. In this setting, iloprost holds a dual position: as first-choice therapy in patients ineligible for revascularization and as complementary therapy in candidates for surgical or endovascular revascularization.