Calcifying epithelial odontogenic tumour of the maxilla: a case report with respect to immunohistochemical findings
Friedrich, R.E.; Zustin, J.
In Vivo 25(2): 259-264
2011
ISSN/ISBN: 0258-851X PMID: 21471544 Document Number: 651493
Calcifying epithelial odontogenic tumour (Pindborg tumour) is a rare benign neoplasm with a poorly understood histogenesis. This report describes a single case of a maxillary calcifying epithelial odontogenic tumour including immunohistochemical analysis. The vast majority of tumour cells were positive for CK5/6 and p63. Furthermore, basal cells also displayed moderate reaction for vimentin and strong membranous positivity for podoplanin. Interestingly, the tumour invaded the dental pulp of the partially disintegrated tooth root. While the tumour showed focal connection with the superficial gingival epithelium and revealed intercellular bridges, the findings of this case study seem to support the suggestion of an epithelial origin of a calcifying epithelial odontogenic tumour derived from the dental lamina.