Peculiarities of cardiac contractile function in patients with arterial hypertension depending on temperament and anxiety state
Klinicheskaia meditsina 89(6): 37-42
2011
ISSN/ISBN: 0023-2149 PMID: 22420192 Document Number: 650687
The aim of the work was to elucidate the relationship between temperament and personal anxiety and between left ventricular myocardium hypertrophy, contractility and diastolic function in 671 men (mean age 54 +/- 1.8 yr) with newly diagnosed grade II arterial hypertension who took no antihypertensive drugs before the study. The tone of vegetative nervous system, serum levels of cortisol, aldosterone, thyroxin, and insulin were measured. EchoCG was used to determine left ventricular myocardium mass (LVMM), LVMM index, the ratio of transmitral blood flow at the beginning and end of diastole, left ventricular ejection and shortening fractions, end-systolic and diastolic size and volume. Phlegmatic and melancholic patients differed from cholerics and sanguinics in the predominance of parasympathetic influences, elevated blood aldosterone and insulin levels in combination with higher LVMM and LVMM index but lower left ventricular systolic and diastolic function. These characteristics were especially well apparent in anxious subjects comprising a risk group for cardiac insufficiency.