Thrombohaemorrhagic syndrome in patients with a myeloproliferative disease with thrombocythemia
Penka, M.; Kissová, J.; Buliková, A.; Zavrelová, J.; Ovesná, J.; Pavlík, T.
Vnitrni Lekarstvi 57(3): 306-311
2011
ISSN/ISBN: 0042-773X PMID: 21495413 Document Number: 650253
Thrombohaemorrhagic syndrome is a clinical syndrome manifesting with concurrent bleeding and thrombosis. It is associated with a range of pathological states, typically with myeloproliferative diseases, paraproteinaemia, liver disease as well as disseminated intravascular coagulation and similar syndromes (so called DIC-like syndrome). Thrombohaemorrhagic syndrome might be a symptom of chronic myeloproliferations, particularly if these are associated with thrombocythemia. It is most frequently linked to essential thrombocythemia. However, in this disease, it seems that the clinical symptoms of bleeding and thrombosis might not be directly determined by the number of platelets, as it would suggest itself, but that this can be consequent to other changes. These may include predisposition to thrombophilia, cardiovascular risk, leukocytosis etc. as well as, for example, platelet dysfunction. The present study focuses on platelet dysfunction in conjunction with clinical symptoms of bleeding and thrombosis.