Impact of IL-18 on inflammation
Tripodi, D.; Maccauro, G.; Anogeianaki, A.; Castellani, M.L.; Pandolfi, F.; Felaco, P.; Toniato, E.; De Lutiis, M.A.; Fulcheri, M.; Tetè, S.; Galzio, R.; Salini, V.; Caraffa, A.; Antinolfi, P.; Frydas, I.; Sabatino, G.; Shaik-Dasthagirisaheb, Y.B.
Journal of Biological Regulators and Homeostatic Agents 25(1): 7-11
2011
ISSN/ISBN: 0393-974X PMID: 21382268 Document Number: 649761
IL-18 is produced by many cell types, such as Kupffer cells, keratinocytes, macrophages, dendritic cells, and activated T cells stimulated by LPS. It is an important regulator of both innate and acquired immune responses. IL-18 plays a central role in rheumatoid arthritis since the T cells and macrophages that invade the synovial. These finding support a role for IL-18 in inflammation, allergy and immune diseases.