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Investigation of antitumor substance from Trichoderma

Podboronov, V.M.; Kuzovnikov, A.E.; Zaĭtseva, A.K.; Smirnova, I.P.; Berezov, T.T.

Antibiotiki i Khimioterapiia 56(9-10): 3-6

2011

ISSN/ISBN: 0235-2990
PMID: 22586896
Document Number: 649649
The effect of L-lysine-alpha-oxidase from Trichoderma harzianum Rifai on the functional activity of T-lymphocytes was investigated. It was shown that in a dose of 35 units/kg administered parentally the enzyme had no suppressive effect on the T-lymphocyte functional activity. An inhibitory effect of L-lysine-a-oxidase on some indices of the macrophages functional activity was observed. L-Lyzine-alpha-oxidase had a selective lymphotropic action and showed no mytostatic activity, which is in favour of the enzyme vs. other antitumor agents.

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