Efficacy of metformin as initial therapy in patients with coronary artery disease and diabetes type 2
Lavrenko, A.V.; Kutsenko, L.A.; Solokhina, I.L.; Rasin, M.S.; Kaĭdashev, I.P.
Likars'ka Sprava 2011(1-2): 89-95
2011
ISSN/ISBN: 1019-5297 PMID: 21954641 Document Number: 649101
The use of metformin during the first month of treatment of patients with coronary artery disease and diabetes type 2 led to the decrease of insulin resistance and reduced activity of systemic inflammation (significant decrease in the concentrations of IL-1, IL-6, IL-8 and TNF-alpha). Reduced activity of systemic inflammation had a beneficial effect on the course of coronary artery disease (significant decrease in the functional class of stable angina). Type 2 diabetes appears to be quite successfully modifiable risk factor for coronary artery disease by the adequate controls.