Osteoporosis treatment by anti-RANKL antibody
Sugimoto, T.
Clinical Calcium 21(8): 1209-1215
2011
ISSN/ISBN: 0917-5857 PMID: 21814027 Document Number: 648824
Anti-RANKL antibody, that is called Denosumab, is a fully human monoclonal antibody to the receptor activator of nuclear factor-κB ligand (RANKL) which blocks its binding to RANK, inhibiting the differentiation, activation and survival of osteoclact. Denosumab given subcutaneously twice yearly for 3 years was associated with a reduction in the risk of vertebral, non-vertebral and hip fractures but not with serious adverse events in postmenopausal women with osteoporosis. Evidence is available about its effect in patients with varying degrees of fracture risk. New horizon would be brought about by Denosumab in Japan, new molecular targeting pharmaceutics in the treatment of osteoporosis.