Developments in research of local bisphosphonate delivery system of implant denture
Zang, C.; Zhai, J.; Meng, Y.; Liang, X.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 28(2): 415-418
2011
ISSN/ISBN: 1001-5515 PMID: 21604513 Document Number: 648721
Dental implant is an advanced prosthodontic treatment widely accepted by patients with missing tooth. However, peri-implant bone loss is still an important reason which limits wider application of the implants to a certain extent. Bisphosphonates is an osteoclastic bone resorption inhibitor that is widely used in clinical practice with the function of inhibiting bone resorption and increasing bone density. As the defect of systemic BPs treatment, local application of BPs in implant has become a research hotspot recently. Calcium phosphate ceramics, polylactic acid, fibrinogen film and collagen membrane have been reported as BPs carriers. This article summarizes the researches on the mechanism of bone regulation and local delivering system of BPs.