Aprepitant successful for controlling nausea and vomiting in a case having difficulty with control treatment in a standard antienemic therapy involving chemotherapy for gallbladder cancer postoperative recurrence
Kawashita, Y.; Shimada, M.; Utsunomiya, T.; Imura, S.; Morine, Y.; Ikemoto, T.; Mori, H.; Hanaoka, J.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 38(5): 861-864
2011
ISSN/ISBN: 0385-0684 PMID: 21566455 Document Number: 648447
This case was a 62-year-old female. She underwent radical surgery for advanced gallbladder cancer 2 years ago after preoperative chemotherapy consisting of GEM/5-FU and CDDP (GFP). Two years after surgical treatment, multiple lung metastases and lymph node metastases appeared, and therefore, GFP chemotherapy was introduced. Rapid emesis occurred at two-cycle medication the first day, and was continued for several days. It was difficult to control the emesis by standard antienemic therapy. We therefore used aprepitant, a new medicine for antiemetic therapy. It had an excellent effect, and chemotherapy for this patient is still being continued.