Research progress of zebrafish used in drug metabolism
Chen, Q.-x.; Zeng, S.
Yao Xue Xue Bao 46(9): 1026-1031
2011
ISSN/ISBN: 0513-4870 PMID: 22121770 Document Number: 648430
Zebrafish is widely used as a model organism in the process of drug discovery. It expresses drug metabolizing enzymes like cytochrome P450 (CYP450), uridine 5'-diphospho-glucuronosyltransferase (UGT) and nuclear receptors like pregnane X receptor (PXR), aryl hydrocarbon receptor (AHR), etc. This article summarized the profiles of main drug metabolizing enzymes and nuclear receptors, and reviewed the advances on xenobiotics metabolism in zebrafish.