Examples of results of pharmaceutical cerebrovascular protection, with special emphasis on the statins
Bajnok, L.ás.ó
Ideggyogyaszati Szemle 64(5-6): 151-156
2011
ISSN/ISBN: 0019-1442 PMID: 21692273 Document Number: 648102
Despite that hypercholesterinemia is not a risk factor of stroke, treatment with statins is able to reduce these events in a clinically relevant degree. Intervention trials suggest that while for primary prevention, statins are effective in conventional dose, after stroke or TIA this is true only if LDL-cholesterol is reduced below 1,8 mmol/L. To reach this goal, usually intensive antilipid treatment is necessary. There are studies showing beneficial impacts of other lipid drugs, beyond statins, i.e. fibrates and fish oil (among the settings of primary, and secondary preventions, respectively). Against cerebro-vascular events, pleiotropic effects of some antihypertensive and antidiabetic medications can also be established.