Hygienic evaluation of the total mutagenic activity of snow samples from Magnitogorsk
Legostaeva, T.B.; Ingel', F.I.; Antipanova, N.A.; Iurchenko, V.V.; Iuretseva, N.A.; Kotliar, N.N.
Gigiena i Sanitariia 4: 47-52
2010
ISSN/ISBN: 0016-9900 PMID: 20873386 Document Number: 647795
The paper gives the results of 4-year monitoring of the total mutagenic activity of snow samples from different Magnitogork areas in a test for induction of dominant lethal mutations (DLM) in the gametes of Drosophila melanogaster. An association was first found between the rate of DLM and the content of some chemical compounds in the ambient air and snow samples; moreover all the substances present in the samples, which had found genotoxic effects, showed a positive correlation with the rate of DLM. Furthermore, direct correlations were first established between the rate of DLM and the air pollution index and morbidity rates in 5-7-year-old children residing in the areas under study. The findings allow the test for induction of dominant lethal mutations (DLM) in the gametes of Drosophila melanogaster to be recommended due to its unique informative and prognostic value for monitoring ambient air pollution and for extensive use in the risk assessment system.