Neuroblastoma in an adult: case report
Miranda Soares, P.Bernardina.; Quirino Filho, S.; Pereira DE Souza, W.; Ferreti Bonan, P.Rogério.; Martelli-Júnior, Hílio.
Revista Medica de Chile 138(9): 1131-1134
2010
ISSN/ISBN: 0034-9887 PMID: 21249281 Document Number: 647326
Neuroblastoma is the most common extracranial solid malignancy in children but rarely described in adults, being 10% of all cases diagnosed after the first decade of life. We report a 23 year-old black woman with a mass at paravertebral region of T3-T5, multiple lesions in vertebral bodies and expanding skull-brain lesion at the right parietal region. Immunohistochemical analysis (negative for CD99, CD20, CD3 and desmin; and positive chromogranin, synaptophysin and NB84) confi rmed the diagnosis of neuroblastoma. The patient was submitted to 12 cycles of chemotherapy receiving VAC (vincristine/doxorubicin/cyclophosphamide) interspersed with ICE (ifosfamide/mesna/etoposide) and doxorubicin was replaced by actinomycin in the 7th cycle. She had good tolerance to this therapy, and has been clinically stable.