Heyde syndrome--the link between aortic stenosis and gastrointestinal bleeding
Vaz, A.; Correia, A.; Martins, B.; Capelo, J.; Ferreira, P.; Henriques, P.; Santos, O.
Revista Portuguesa de Cardiologia Orgao Oficial da Sociedade Portuguesa de Cardiologia 29(2): 309-314
2010
ISSN/ISBN: 0870-2551 PMID: 20545255 Document Number: 647081
Aortic valve stenosis can be complicated by gastrointestinal bleeding from angiodysplasia. A deficiency of high molecular weight multimers of von Willebrand factor (vWF) (type 2A von Willebrand disease) provides the link between this association, which is known as Heyde syndrome. Aortic valve replacement corrects the vWF abnormalities with long-term resolution of gastrointestinal bleeding. The authors present a case report and a review of this association.