A case of early poorly-differentiated neuroendocrine carcinoma of stomach
Seshimo, K.; Tanaka, N.; Yamashita, Y.; Oishi, M.; Kodera, M.; Yamamura, M.; Katoh, H.; Ikeda, H.; Yokomichi, N.; Toshima, T.; Kawai, Y.; Shibagaki, K.; Maejima, R.; Fujita, H.; Ichimura, K.; Takita, K.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 37(2): 319-321
2010
ISSN/ISBN: 0385-0684 PMID: 20154494 Document Number: 645974
A 45-year-old male was admitted to our hospital complaining of anemia. Gastric endoscopy showed a type IIa+IIc tumor at the anterior wall of the gastric angle. Based on the pathology of the biopsy specimen, poorly-differentiated adenocarcinoma was diagnosed. Computed tomography scans showed regional lymph node swelling. Distal gastrectomy with a D2 lymph node dissection was performed. On pathology, the tumor was immunohistochemically positive for chromogranin A and synaptophysin. The Ki67 index was 70%. The tumor was diagnosed as poorly-differentiated neuroendocrine carcinoma of the stomach. He was treated with S-1 and CPT-11. Neuroendocrine cell carcinoma of the stomach is rare and usually has a very poor prognosis. Thus, we are reporting this case of early poorly-differentiated neuroendocrine carcinoma of the stomach that was curatively resected and had 12-month survival without recurrence.