Genomics and systems biology in malaria drug discovery
Dharia, N.V.; Chatterjee, A.; Winzeler, E.A.
Current Opinion in Investigational Drugs 11(2): 131-138
2010
ISSN/ISBN: 1472-4472 PMID: 20112162 Document Number: 644441
A disadvantage of using target-based drug discovery in the search for new antimalarials is that predicting which targets will be essential for parasite growth in mammalian hosts is often difficult. In addition, well-validated targets may not yield new classes of compounds. Finally, resistance may emerge more quickly for compounds that interact with a single cellular target.