Meta analysis on effect of local application of chlorhexidine with scaling and root planing
Lin, L.; Li, X.-y.; Liang, L.-y.; Jiang, X.-j.; Li, Z.; Pan, Y.-p.
Shanghai Kou Qiang Yi Xue 19(2): 124-128
2010
ISSN/ISBN: 1006-7248 PMID: 20485970 Document Number: 643901
Meta analysis was used to assess the effect of local drug delivery system of chlorhexidine (CHX) as an adjunct to scaling and root planing(SRP) versus SRP alone in patients with chronic periodontitis. The selected studies of randomized controlled trials(RCTs) were pooled from six major electronic database up to May,2009 as CHX plus SRP versus SRP with at least 3 months of follow-up. Several English full texts were hand searched. Outcome measures were probing depth(PD) reduction and clinical attachment level (CAL)gain. Seven studies that met inclusion criteria were entered into the Meta analysis. A significant mean reduction of PD in patients with CHX plus SRP was observed, but there were no significant difference in CAL between the two treatment groups. Chlorhexidine as an adjunct to SRP could reduce probing depth in the treatment of chronic periodontitis. Supported by Research Project of Education Bureau of Liaoning Province(Grant No.20061021).