Expression of aquaporin-1 in nasopharyngeal cancer tissues
Li, Q.; Zhang, B.
Journal of Otolaryngology - Head and Neck Surgery 39(5): 511-515
2010
ISSN/ISBN: 1916-0216 PMID: 20828513 Document Number: 643694
To investigate the expression of aquaporin-1 (AQP1) in nasopharyngeal tumour and nontumour tissues. Thirty nasopharyngeal biopsy samples were collected and examined with both immunohistochemistry and real-time fluorescence quantitative polymerase chain reaction (RT-PCR) to detect the expression level of AQP1 in tissues. Immunohistochemistry data suggested that AQP1 was expressed in both nasopharyngeal tumour and normal tissues, but tumour tissues were stained a lot stronger than nontumour tissues. RT-PCR analysis further confirmed the overexpression of AQP1 in tumour tissues; migrated tumour tissue had even higher expression. The expression level of aquaporin-1 in nasopharyngeal cancer tissue could be involved in tumour migration.