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Age-Disparate Partnerships and Risk of HIV-1 Acquisition Among South African Women Participating in the VOICE Trial

Balkus, J.E.; Nair, G.; Montgomery, E.T.; Mishra, A.; Palanee-Phillips, T.; Ramjee, G.; Panchia, R.; Selepe, P.; Richardson, B.A.; Chirenje, Z.M.; Marrazzo, J.M.

Journal of Acquired Immune Deficiency Syndromes 70(2): 212-217

2015

ISSN/ISBN: 1944-7884
PMID: 26049280
DOI: 10.1097/qai.0000000000000715
Document Number: 642387
A recent analysis from South Africa reported no association between age-disparate relationships and HIV-1 acquisition. We assessed the association between male partner age and HIV-1 acquisition among South African women participating in the VOICE trial. Of 4077 women enrolled, 3789 had complete data; 26% and 5% reported having a partner >5 and >10 years older at enrollment, respectively. Reporting a partner >5 years older (hazard ratio = 1.00; 95% confidence interval: 0.74 to 1.35) or >10 older (hazard ratio = 0.92; 95% confidence interval: 0.49 to 1.74) was not associated with HIV-1 acquisition. These data corroborate recent reports and may suggest a shift in local epidemiology of heterosexual HIV-1 transmission.

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