IARC revision on dioxin and some dioxin-like compounds
Catalani, S.
Giornale Italiano di Medicina del Lavoro Ed Ergonomia 32(1): 79-81
2010
ISSN/ISBN: 1592-7830 PMID: 20464981 Document Number: 640956
Since 1997 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) has classified in Group 1 carcinogens by IARC essentially on based on mechanistic considerations. In the last review of human carcinogens IARC confirmed this classification also with epidemiological evidences. Following chemical-physical and mechanistics considerations, in particular the same AhR-mediated action, for two other dioxin-like compounds, the PCB126 and the PeCDF the classification in group 1 was suggested. This note reports and comments this IARC revision.