Somatostatin receptor imaging with (111) In-pentetreotide in gastro-intestinal tract and lung neuroendocrine tumors-Impact on targeted treatment
Gerasimou, G.; Moralidis, E.; Gotzamani-Psarrakou, A.
Hellenic Journal of Nuclear Medicine 13(2): 158-162
2010
ISSN/ISBN: 1790-5427 PMID: 20808990 Document Number: 640713
Somatostatin is a neuropeptide that confers a wide range of pharmacological properties. Indium-111-tagged pentetreotide ((111)In-P) is a radiolabeled analogue of somatostatin indicated for the in vivo scintigraphic localization of neuroendocrine tumors (NET). In cases of NET of the gastro-intestinal tract we describe the sensitivity compared to conventional anatomical imaging modalities and especially the possibility that (111)In-P may change therapeutic management into up one fourth of the patients. In cases of small cell lung carcinoma it has been used for the evaluation of somatostatin receptor status and a substantial tool for differentiation between limited and extensive disease, especially when combined with anatomical imaging methods. We also describe the radiolabeled with yttrium-90 or lutetium-177 somatostatin analogue peptides in the treatment of NET and also the use of (111)In-P for the selection of patients for targeted treatment.