Endothelin in cardiovascular diseases pathophysiology
Dobrek, Łu.; Thor, P.
Polski Merkuriusz Lekarski Organ Polskiego Towarzystwa Lekarskiego 28(166): 289-292
2010
ISSN/ISBN: 1426-9686 PMID: 20491339 Document Number: 640538
Endothelin (ET-1) is the polypeptide about wide spectrum of physiological effects. The results of numerous experimental and clinical investigations showed its essential role also in the pathophysiology of various cardiovascular diseases (arteriosclerosis, heart failure, pulmonary hypertension, renal failure) and some neoplastic conditions. Thus, ET-1 blocking becomes an interesting tool of modern pharmacotherapy, targeted on neurohormonal mechanisms. The article briefly describes biochemical properties of ET-1 and ET and pathophysiological role of ET-1 in selected cardiovascular diseases.