Saturation of the Polish mitochondrial DNA database
Daca, P.; Mielnik-Sikorska, M.; Bednarek, J.ła.; Grzybowski, T.
Archiwum Medycyny Sadowej i Kryminologii 60(4): 263-269
2010
ISSN/ISBN: 0324-8267 PMID: 21863734 Document Number: 639221
The main objective of the study was a statistical evaluation of Polish mitochondrial DNA database, consisting of 1253 maternally unrelated individuals from seven different regions of Poland. Four relevant parameters were examined: haplotype diversity, nucleotide diversity, number of polymorphic positions and number of haplotypes, including HVS I and HVS II mtDNA regions. The results show that while haplotype and nucleotide diversities have already reached saturation level, the number of haplotypes and polymorphic positions rises continuously inside the database. These results indicate a need for a substantial increase in the number of haplotypes in Polish mitochondrial DNA database.