Pharmacourodynamic non-invasive studies in patients with prostatic adenoma
Danilov, V.V.; Vasil'chenko, A.V.; Danilova, T.I.; Besedin, S.A.; Borshchenko, S.A.; Danilov, V.V.
Urologiia 6: 16-19
2010
ISSN/ISBN: 1728-2985 PMID: 21427987 Document Number: 638461
After examination 47 patients with prostatic adenoma (mean age 63 years) received a course of alpha1-adenoblocker (omsulosin in a dose 0.4 mg/day). A three-day uroflowmetric monitoring was made at home before and after treatment. The findings were assessed with Liverpool nomo-gram by maximal flow. Omsulosin treatment was found to change voiding structure, to identify the obstructive component due to displacement of the flow characteristics to the low centiles of the nomogram. Thus, long-term treatment with alpha1-adrenoblockers can be used as a pharmacourodynamic test to detect infravesical obstruction in patients with prostatic adenoma.