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Pharmacokinetics of hopantenic acid upon peroral administration

Karlina, M.V.; Pozharitskaia, O.N.; Kosman, V.M.; Shikov, A.N.; Lazukina, M.A.; D'iachuk, G.I.

Eksperimental'naia i Klinicheskaia Farmakologiia 73(8): 46-48

2010

ISSN/ISBN: 0869-2092
PMID: 20919560
Document Number: 638126
A simple, specific and sensitive RP-HPLC method with UV detection for the determination of hopantenic acid in human blood plasma has been developed. The pharmacokinetics of drug pantocalcin upon single peroral administration was investigated on 18 healthy volunteers. The peak of hopantenic acid in blood plasma was achieved at 1.56 h and the elimination half life was 6.68 h. No hopantenic acid in blood plasma is found in 48 h.

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